A key challenge in the discovery and development of biologics is that selected lead candidates are often identified to have sub-optimal biophysical properties during late-stage development, resulting in wasted time and money. What if there was an integrated platform that enabled early-stage evaluation of developability profiles of lead candidates?
There is! We call it the Proteros Integrated Biologics Workbench.
Proteros combines iterative and orthogonal technologies and readouts to de-risk biologics lead candidate development:
- Perform Protein expression, purification feasibility as well as optimization
- Identify physicochemical properties (purity/impurity, charge, hydrophobicity, PTMs, etc.)
- Determine target-antigen engagement (KD, kon, koff, avidity, selectivity)
- Epitope mapping for structure-coded target specificity (x-ray crystallography & cryo-EM)
- Assess molecules' developability and stability (from orthogonal readouts for functional and target integrity)
- Identify complex binding modes of multivalent and multi-specific formats (SPR & cryo-EM)
Let us help you select the most promising leads candidates for development in your pipeline so you can Reach Right Faster.
