Gallery Structures
- > 200 relevant targets ready for Protein-Ligand-Structure determination
- Saving valuable time through pre-defined protein production, purification, analytics and crystallization conditions
Gene-to-Structure
- From construct design, protein production, broad crystallization screen, optimization of crystals for high-resolution structure, Synchrotron data collection, to structure solution and refinement
- High-resolution protein-ligand-structures (PLS) or apo structures
Custom Services
- Initial screening only
- Crystal optimization only (incl. Free Mounting System "FMS")
- Data collection (Synchrotron) only
- Structure solution /refinement only
Protein for Crystallization
- Establishment of protein production
- Biophysical characterization of protein quality
Deliverable: Protein satisfying the high-quality standards of crystallography
Crystallization
- up to 2000 initial crystallization conditions tested in parallel
- Reliable drop setting using robotic platform
- Automated imaging systems at 4°C and 20°C
- In-house x-ray facility to test crystals
- Established protocols for LCP and robotic LCP drop setting
Deliverable: Protein crystals suitable for x-ray
Data Quality Enhancement
- Humidity controlled improvement of data quality
- Advanced laser controlled improvement of data - FMS laser
- In-house rotating anode X-ray analysis for crystal evaluation
Deliverable: Protein crystals optimized for high-resolution crystallography
Structural Analysis
- Data collection at the SLS beamline
- Automated pipeline for data processing and structure solution (MIR/MAD/SAD and Molecular Replacement)
- Stringent quality control process for all structures delivered (PDB standard)