X-ray Crystallography Services

We offer three types of Protein X-Ray Crystallography Services.

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Gallery Structures

  • > 200 relevant targets ready for Protein-Ligand-Structure determination
  • Saving valuable time through pre-defined protein production, purification, analytics and crystallization conditions
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Gene-to-Structure

  • From construct design, protein production, broad crystallization screen, optimization of crystals for high-resolution structure, Synchrotron data collection, to structure solution and refinement
  • High-resolution protein-ligand-structures (PLS) or apo structures
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Custom Services

  • Initial screening only
  • Crystal optimization only (incl. Free Mounting System "FMS")
  • Data collection (Synchrotron) only
  • Structure solution /refinement only

FIND A GALLERY STRUCTURE

Search by variant or use the dropdown to search by Swiss Prot-ID or Catalog No.

VIEW ALL GALLERY PRODUCTS

Service Process

 

Protein for Crystallization

  • Establishment of protein production
  • Biophysical characterization of protein quality

Deliverable: Protein satisfying the high-quality standards of crystallography

Crystallization

  • up to 2000 initial crystallization conditions tested in parallel
  • Reliable drop setting using robotic platform
  • Automated imaging systems at 4°C and 20°C
  • In-house x-ray facility to test crystals
  • Established protocols for LCP and robotic LCP drop setting

Deliverable: Protein crystals suitable for x-ray

Data Quality Enhancement

  • Humidity controlled improvement of data quality
  • Advanced laser controlled improvement of data - FMS laser
  • In-house rotating anode X-ray analysis for crystal evaluation

Deliverable: Protein crystals optimized for high-resolution crystallography

Structural Analysis

  • Data collection at the SLS beamline
  • Automated pipeline for data processing and structure solution (MIR/MAD/SAD and Molecular Replacement)
  • Stringent quality control process for all structures delivered (PDB standard)
Deliverable: High-resolution protein (apo) or protein-ligand-structure (PLS) crystal

Proteros  Statistics

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proven track record with pharma and biotech partners in US, Europe and Japan

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serve most of the world's largest pharma companies

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peer-reviewed publications

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protein structures elucidated