Qualified Hits

Generation of qualified hits according to your predetermined and fully customizable Research Target Profile (RTP).

We work as your high-performance discovery engine against a single proposal (FTE or FF/SF) with budget frame, timelines, milestones, and a final project milestone. 

  • Defined key milestone-based go/no-go decision points
  • Regular reporting schedules and joint steering committee meetings as required

Discover

The Target-to-Qualified-Hit process

Once you nominate the target and desired mode of inhibition, Proteros will get to work assembling the right team to engage in meaningful scientific discussions. This will be followed by the establishment of a strategy to deliver your qualified hits. Then we will design a completely customized project plan before executing your discovery solution. This is how we give you the confidence to quickly advance your project to the next stage of drug discovery.

At Proteros we pride ourselves on delivering reliable results. Our scientific expertise warrants the design of scientifically relevant experiments that ultimately reach the right outcomes.

Team Assembly

A handpicked team from:

  • 17 assay, biophysics and screening experts led by 7 PhDs with access to cutting-edge laboratories
  • 50+ protein scientists
  • 13 PhDs with structural biology and drug discovery backgrounds

Scientific Discussions

Our experts engage you in detailed discussions to understand your needs and your protein. Our attention to detail is how we are able to solve even the most challenging structures.

Strategy

We devise a well-rounded strategy to perfectly fit your situation and your protein. With all of our facilities under one roof, there is no compromise and we will always strive for the best possible approach.

Customized project plan

Following on from the strategy we will produce a detailed project plan to make sure that your drug discovery project will be completed on time.

Execution

The project plan is then executed by your team of experts with clear and open communication throughout.

Platform Establishment

Establishment of protein production, assay systems, and structural biology platforms.

Library Screening

We use the agreed libraries and assay platform to uncover hits against the respective protein target.

Hit confirmation and characterization

Orthogonal assays used to confirm and characterize hits.

Structural Elucidation

X-ray crystallography and/or cryo-EM used to interrogate protein-ligand binding mode.

Proteros Statisitcs

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Pharma and biotech partners

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publications

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structures elucidated

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projects completed

Why use the Proteros Target-to-Qualified-Hits platform

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